Journal of International Oral Health

REVIEW ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 5  |  Page : 429--434

c-KIT mutation role in oral malignant melanoma pathway: A narrative review


Nanda Rachmad Putra Gofur1, Aisyah Rachmadani Putri Gofur2, Hernalia Martadila Putri3 
1 Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur, Indonesia
2 Faculty of Dental Medicine – Universitas Airlangga, Surabaya, Indonesia
3 Pakis Public Health Center, Surabaya, Indonesia

Correspondence Address:
Dr. Nanda Rachmad Putra Gofur
Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur.
Indonesia

Aim: To investigate the role of the c-KIT mutation in oral malignant melanoma (OMM). Materials and Methods: The search strategy includes randomized control trials and clinical trials from the databases of PubMed Central, Cochrane, EBSCO, and MEDLINE from January 1999 to May 2019. A total of seven clinical trials that met all inclusion criteria were included in this systematic review. Results: A previous study found that c-KIT can initiate the activation variety of downstream pathways, including the MAPK/MEK and PI3K/AKT pathways, which play important roles in cancer development. The c-KIT mutation has resulted in a loss of heterozygosity at 12p13, and loss of p27KIP1 protein has been detected. Activating c-KIT mutations in the juxtamembrane and other domains has been considered as an oncogene and also a therapeutic target in various tumors. Conclusion: c-KIT is playing the role of an important target in the research of molecular therapy in patients with metastatic OMM with c-KIT mutations.


How to cite this article:
Gofur NR, Gofur AR, Putri HM. c-KIT mutation role in oral malignant melanoma pathway: A narrative review.J Int Oral Health 2021;13:429-434


How to cite this URL:
Gofur NR, Gofur AR, Putri HM. c-KIT mutation role in oral malignant melanoma pathway: A narrative review. J Int Oral Health [serial online] 2021 [cited 2021 Nov 29 ];13:429-434
Available from: https://www.jioh.org/article.asp?issn=0976-7428;year=2021;volume=13;issue=5;spage=429;epage=434;aulast=Gofur;type=0