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Year : 2023  |  Volume : 15  |  Issue : 5  |  Page : 463-468

Comparative estimation of C-terminal cross-linked telopeptide of type I collagen levels in gingival crevicular fluid in diabetic and nondiabetic patients with chronic periodontitis: A prospective clinical study

1 Department of Periodontology, Manav Rachna Dental College, FDS, MRIIRS, Faridabad, Haryana, India
2 Department of Biochemistry, Manav Rachna Dental College, FDS, MRIIRS, Faridabad, Haryana, India

Correspondence Address:
Dr. Anushree Ningombam
Singjamei makha Khongnang Pheidekpi, Imphal, Manipur 795 008
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jioh.jioh_135_23

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Aim: To estimate C-terminal cross-linked telopeptide (CTx) levels in GCF, using ELISA in diabetic and nondiabetic patients with chronic periodontitis. Materials and Methods: A total of 42 patients were recruited: 21 type II diabetic patients with chronic periodontitis (group A) and 21 nondiabetic patients with chronic periodontitis (group B). Scaling and root planing (SRP) were done in groups, followed by collection of GCF samples and recording of clinical variables. Measurements for clinical indicators of periodontal health were taken on 0 day (baseline), first and after third month. The Ctx level of GCF was taken at baseline and after 3 months using enzyme-linked immunosorbent assay (ELISA). GPower software (version 3.0) was used. Paired t tests and Student’s t tests as well as parametric tests were used to analyze the results. The threshold for significance was fixed at P < 0.05. Result: Following SRP, there was a significant reduction in Ctx levelsand an improvement in clinical parameters in both groups. There is a negative correlation uniting CTx quantity with an improvement in periodontal conditions in both diabetic and nondiabetic patients. Conclusion: CTx levels in both diabetic and nondiabetic candidates with chronic periodontitis infection were reduced after nonsurgical periodontal therapy.

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