| ORIGINAL RESEARCH |
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| Year : 2023 | Volume
: 15
| Issue : 4 | Page : 367-371 |
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Comparison of total antioxidant capacity level in patients with HIV/AIDS and healthy individuals
Dewi Zakiawati1, Irna Sufiawati2, Herry Herman3
1 Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia
2 Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia
3 Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia
Correspondence Address:
Dr. Irna Sufiawati
Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, J. Sekeloa No.1 Bandung, West Java 40132
Indonesia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jioh.jioh_261_21
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Aim: The primary aim of this study was to analyze differences in total antioxidant capacity (TAOC) levels in patients with HIV/AIDS compared with healthy individuals. The secondary aim of this study was to investigate factors that may contribute to the TAOC level in patients with HIV/AIDS including viral load, CD4 counts, and oral lesions. Materials and Methods: This research was a cross-sectional study. Fifty-eight samples from patients with HIV/AIDS and healthy individuals were calculated using the purposive sampling method. The TAOC level from the stored biological material was measured using enzyme-linked immunosorbent assay (ELISA) with the colorimetric method. The data were analyzed statistically using the chi-square to see the difference in TAOC levels between HIV and healthy individuals. Spearman’s correlation test was used to analyze the correlation between TAOC and other contributing factors. Results: The serum samples were collected from 35 patients with HIV/AIDS (74.3% men and 25.7% women) and 23 healthy individuals (65.2% men and 34.8% women). The samples were mostly obtained from healthy individuals aged 25–34 and 35–44 years old with a 47.8% and 37.1%, consecutively. Similarly, the HIV/AIDS samples are also dominated by the same age group which shares the exact percentage of both groups (37.1%). The TAOC level in patients with HIV/AIDS was lower significantly than the healthy individuals (P < 0.05). However, the TAOC level had a very weak statistical correlation with viral load (P = 0.03), CD4 (P = 0.46), and oral lesions (P = 0.44). Conclusions: In this study, the TAOC level in patients with HIV/AIDS was lower than the healthy individuals, and did not correlate to the number of viral loads, CD4 cell count, and oral lesions of patients with HIV/AIDS. |
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