JIOH on LinkedIn JIOH on Facebook
  • Users Online: 307
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL RESEARCH
Year : 2022  |  Volume : 14  |  Issue : 4  |  Page : 403-408

The effect of alpha-mangostin on interleukin-10 and collagen 1A1 gene in the inflammation process: An experimental in-vitro study


1 Residency Program of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
2 Academic Staff of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
3 Academic Staff of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
4 Staff of Oral and Maxillofacial Surgery Department, Pioneer Dental College and Hospital, Bangladesh

Correspondence Address:
Dr. Andra Rizqiawan
Academic Staff of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Jl. Prof. Moestopo, 47, Surabaya 60132
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JIOH.JIOH_48_22

Rights and Permissions

Aims: Bone resorption after tooth extraction can cause serious problems on subsequent denture implants and restorative dentistry procedures that rely on the bone healing process. The peel of the mangostin fruit is one of the natural components that can help with wound healing. Its constituents, particularly alpha-mangostin, have antifungal, antioxidant, antiviral, antibacterial, and anti-inflammatory properties. The research was carried out because there was an effort to speed up the healing process following tooth extraction and because of the high potential of alpha-mangostin. The aim of this study is to see whether taking alpha-mangostin decreases interleukin-10 (IL-10) and increases collagen 1A1 expression in the inflammation process. Materials and Methods: This study was a post-test-only control group design. An in-vitro experiment was conducted on the following four groups. Then lipopolysaccharide (LPS) and alpha-mangostin were inducted into cell culture. In osteoblast cell culture 7F2, real-time polymerase chain reaction was performed to see markers collagen 1A1 and IL-10. The research was statistically analyzed, using a variance test and one-way analysis of variance. Results: The highest IL-10 gene expression was found in group induction with LPS, but there was no significant difference in IL-10 expression between the groups. The highest collagen 1A1 gene expression was found in a group that received induction with LPS and alpha-mangostin, but there was not a significant difference in collagen 1A1 expression between the groups. Conclusion: Alpha-mangostin induction effectively reduces inflammation and IL-10 expression, while increasing collagen 1A1 expression.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed130    
    Printed14    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal