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Year : 2021  |  Volume : 13  |  Issue : 5  |  Page : 429-434

c-KIT mutation role in oral malignant melanoma pathway: A narrative review

1 Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur, Indonesia
2 Faculty of Dental Medicine – Universitas Airlangga, Surabaya, Indonesia
3 Pakis Public Health Center, Surabaya, Indonesia

Correspondence Address:
Dr. Nanda Rachmad Putra Gofur
Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JIOH.JIOH_6_21

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Aim: To investigate the role of the c-KIT mutation in oral malignant melanoma (OMM). Materials and Methods: The search strategy includes randomized control trials and clinical trials from the databases of PubMed Central, Cochrane, EBSCO, and MEDLINE from January 1999 to May 2019. A total of seven clinical trials that met all inclusion criteria were included in this systematic review. Results: A previous study found that c-KIT can initiate the activation variety of downstream pathways, including the MAPK/MEK and PI3K/AKT pathways, which play important roles in cancer development. The c-KIT mutation has resulted in a loss of heterozygosity at 12p13, and loss of p27KIP1 protein has been detected. Activating c-KIT mutations in the juxtamembrane and other domains has been considered as an oncogene and also a therapeutic target in various tumors. Conclusion: c-KIT is playing the role of an important target in the research of molecular therapy in patients with metastatic OMM with c-KIT mutations.

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