JIOH on LinkedIn JIOH on Facebook
  • Users Online: 4139
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 5  |  Page : 429-434

c-KIT mutation role in oral malignant melanoma pathway: A narrative review


1 Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur, Indonesia
2 Faculty of Dental Medicine – Universitas Airlangga, Surabaya, Indonesia
3 Pakis Public Health Center, Surabaya, Indonesia

Correspondence Address:
Dr. Nanda Rachmad Putra Gofur
Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jawa Timur.
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JIOH.JIOH_6_21

Rights and Permissions

Aim: To investigate the role of the c-KIT mutation in oral malignant melanoma (OMM). Materials and Methods: The search strategy includes randomized control trials and clinical trials from the databases of PubMed Central, Cochrane, EBSCO, and MEDLINE from January 1999 to May 2019. A total of seven clinical trials that met all inclusion criteria were included in this systematic review. Results: A previous study found that c-KIT can initiate the activation variety of downstream pathways, including the MAPK/MEK and PI3K/AKT pathways, which play important roles in cancer development. The c-KIT mutation has resulted in a loss of heterozygosity at 12p13, and loss of p27KIP1 protein has been detected. Activating c-KIT mutations in the juxtamembrane and other domains has been considered as an oncogene and also a therapeutic target in various tumors. Conclusion: c-KIT is playing the role of an important target in the research of molecular therapy in patients with metastatic OMM with c-KIT mutations.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed433    
    Printed18    
    Emailed0    
    PDF Downloaded40    
    Comments [Add]    

Recommend this journal