JIOH on LinkedIn JIOH on Facebook
  • Users Online: 6736
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 355-361

The association between vitamin D/25(OH)D and reproductive hormone in young women with recurrent aphthous stomatitis: An observational study

1 Department of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
2 Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
3 Department of Dental Public Health, Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
PhD Hendri Susanto
Department of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Jalan Denta 1, Sekip Utara, Yogyakarta.
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jioh.jioh_262_18

Rights and Permissions

Aim: To investigate the association between vitamin D/25-hydroxyvitamin D [25(OH)D] level and reproductive hormone in women with recurrent aphthous stomatitis (RAS). The reproductive hormonal change suggested contributing to development of RAS in women. Studies have also shown that vitamin D deficiency may contribute to the development of RAS. So far, there is no study that reveals the association between vitamin D/25(OH)D and reproductive hormone in RAS. Materials and Methods: A cross-sectional study was performed on 38 female patients with RAS without any systemic history, any habit, or on any medications. All subjects with RAS underwent intraoral examination and hormonal level assessment to examine reproductive hormones (follicle-stimulating hormone [FSH], luteinizing hormone [LH], estradiol, and progesterone), cortisol, and vitamin D/25(OH)D. The demographic characteristics of oral ulcers, predisposing factors, and pain (visual analog scale [VAS]) scores of RAS were also obtained from all participants. The characteristics of subjects, severity of RAS, FSH, LH, estradiol, progesterone, cortisol, and vitamin D/25(OH)D were presented descriptively. Results: All subjects had mean value of estradiol (93.99 ± 81.34 pg/mL), progesterone (0.73 [0.44 to 3.73 ng/mL]), FSH (4.24 ± 1.90 mIU/mL), LH (8.12 ± 5.76 mIU/mL), cortisol (8.13 ± 2.70 µg/mL), and had low mean value of serum vitamin D/25(OH)D (10.88 ± 3.21 ng/mL) which was categorized with vitamin D deficiency. The result of Pearson correlation test showed a significant positive correlation between mean LH and vitamin D/25(OH)D (P < 0.05). Conclusion: All subjects with RAS have vitamin D deficiency and vitamin D is correlated with LH.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded150    
    Comments [Add]    

Recommend this journal