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Year : 2020  |  Volume : 12  |  Issue : 3  |  Page : 189-196

Triple antibiotic paste––Challenging intracanal medicament: A systematic review

School of Dental Sciences, Health Campus Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

Correspondence Address:
Dr. Saleem D Makandar
School of Dental Sciences, Health Campus Universiti Sains Malaysia 16150, Kubang Kerian, Kelantan.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JIOH.JIOH_213_19

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Aim: To evaluate and compare the performance of triple antibiotic paste (TAP) as intracanal medicaments during the root canal treatment. Materials and Methods: Search strategy included the in vivo studies, in vitro studies, and clinical trials from the databases of PubMed Central, Cochrane, EBSCO, and MEDLINE from January 1981 to August 2019. A total of 223 articles were searched, of which 39 articles were relevant to our study. The searched articles were clinical trials, case reports, and original studies that met with inclusion criteria. Of which, 13 articles were used for quantitative synthesis. A systematic review was performed for TAPs, antibacterial efficiency, effect on mechanical properties, discoloration effect, and cytotoxicity on stem cells. Results: In the included studies, the systematic review articles, the evidence of antibacterial efficiency of TAP is significantly more efficient compared to other medicaments techniques. The mechanical properties has been evaluated, there is a mild reduction in the mechanical properties of the dentin. TAP plays a significant role in reducing the chronic periapical infections. It shows minimal discoloration effect and minimal cytotoxicity to dental pulp stem cell (DPSC) as compared to calcium hydroxide and Ledermix. Conclusion: This systematic review of available data and evidences reveals that TAP is significantly more efficient than the other intracanal medicaments because of its minimal discoloration effect on teeth and less toxic nature to the DPSCs.

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