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REVIEW ARTICLE
Year : 2016  |  Volume : 8  |  Issue : 11  |  Page : 1043-1048

Oral Squamous Cell Carcinoma and Anoikis: A Brief Review on Recent Advances


1 Senior Lecturer, Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India
2 Associate Professor, Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India
3 Professor, Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India
4 Associate Professor, Department of Maxillofacial and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia

Correspondence Address:
Sachin C Sarode
Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune - 411 018, Maharashtra

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Source of Support: None, Conflict of Interest: None


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Anoikis resistance is a crucial process responsible for metastasis of cancer cells in oral squamous cell carcinoma (OSCC). Array of molecules is responsible for modulation of anoikis which directly or indirectly results in anoikis resistance. They alter the specific molecules like hepatocyte growth factor, caveolin, tetramolybdenum which play an important role in anoikis. Moreover, they modify different pathways such as Akt, mitogen- activated protein kinase, Wnt/catenin to overcome metastasis. It will be beneficial to review anoikis associated recent advancements in the English medical literature so that it will help in implicating novel therapeutic approaches to overcome metastasis and thus improving the prognosis of the OSCC patients.


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